Description
Climen Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Estradiol Valerate , Cyproterone Acetate
Used For
Hormone Replacement Therapy
How it works
Estradiol is a steroid hormone and, therefore, can easily cross the cell membrane. Estrone binds to its specific intracellular receptor and regulates DNA transcription for protein formation. The mechanism of action of cyproterone involves blocking the androgen receptor. Cyproterone is an antiandrogen. It suppresses the actions of testosterone (and its metabolite dihydrotestosterone) on tissues.
Climen Tablets Usage And Safety
Dosage
Estradiol Valerate , Cyproterone Acetate
Side Effects
A feeling of tension in the breasts, intermenstrual bleeding, gastric complaints, nausea and changes of body weight and libido occur. Oedema, headache and depressive moods occur.
Drug Interactions
Various substances (eg barbiturates, phenylbutazone, hydantoins, rifampicin) accelerate the metabolism of steroid hormones (possible impairment of effect); reduced substance levels have also been observed on concurrent use of some antibiotics (eg ampicillin) as a result of alteration of the intestinal flora.
Indication
It is indicated in patients (with intact uteri) suffering from climacteric symptomatology. This therapy may be used as an adjunct in preventing osteoporosis in postmenopausal women.
When not to Use
Pregnancy, lactation, severe disturbances of liver function, jaundice or persistent itching during a previous pregnancy, previous or existing tumours of the liver, uterus, ovaries or breast or a suspicion of such tumours, endometriosis, existing or previous thromboembolic processes, severe diabetes mellitus with vascular changes, sickle-cell anaemia, disturbances of lipometabolism,
Climen Tablets Precautions
Precaution
Strict medical supervision is necessary in patients with diabetes, hypertension, varicose veins, a history of phlebitis, otosclerosis, multiple sclerosis, epilepsy, porphyria, tetany, chorea minor.
Climen Tablets Warnings
Warning 1
The requirement for antidiabetics or insulin can change as a result of an effect on glucose tolerance.
Warning 2
Before it is used, a thorough general medical (including measurement of blood pressure, analysis of urine for sugar, if applicable performance of special liver diagnostics as well) and gynaecological (including the breast and a cytological smear of the cervix and portio) examination should be performed .
Warning 3
Tablet-taking is always started from the blister marked Start and continued daily in the direction of thearrows until all 28 tablets have been taken.
Climen Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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