Nebcin Injection 80mg 1Amp x 2mL

Description

Product Name: Nebcin Injection
Strength: 80mg per 2mL ampoule
Form: Sterile injectable solution
Active Ingredient: Tobramycin
Pharmaceutical Class: Aminoglycoside antibiotic
Route of Administration: Intramuscular (IM) or Intravenous (IV) injection

Product Overview

Nebcin Injection contains Tobramycin, a broad-spectrum aminoglycoside antibiotic used to treat serious bacterial infections. It is particularly effective against Gram-negative bacteria and is often reserved for infections that are resistant to other antibiotics. Tobramycin works by inhibiting bacterial protein synthesis, leading to cell death.

Indications

Nebcin is indicated for the treatment of serious infections caused by susceptible bacteria, including:

• Septicemia
• Lower respiratory tract infections (e.g., pneumonia)
• Urinary tract infections
• Skin and soft tissue infections
• Intra-abdominal infections
• Bone and joint infections
• Meningitis (in select cases)
• Post-surgical infections
• Neonatal sepsis (under medical supervision)

Dosage and Administration

• Adults: Usual dose is 3–5 mg/kg/day in divided doses every 8 hours (IV or IM), depending on severity.
• Children and Neonates: Dosage is weight-based and adjusted by age and renal function.
• Method: May be given via deep intramuscular injection or slow intravenous infusion.
• Duration: Determined by infection type and response to treatment.

Renal function must be assessed before and during treatment to adjust dosing appropriately.

Contraindications

Do not use Nebcin in patients with:

• Known hypersensitivity to tobramycin or other aminoglycosides
• Pre-existing hearing loss or vestibular dysfunction
• Severe renal impairment unless closely monitored
• Myasthenia gravis

Precautions

• Monitor kidney function and hearing during prolonged therapy
• Caution in elderly patients and those with dehydration
• Ensure adequate hydration during treatment
• Avoid concurrent use with other nephrotoxic or ototoxic drugs
• Dosage adjustments are necessary in renal impairment

Possible Side Effects

Common:

• Injection site discomfort
• Nausea
• Headache
• Mild fever

Serious:

• Ototoxicity (hearing loss, tinnitus, dizziness)
• Nephrotoxicity (kidney damage)
• Neuromuscular blockade
• Allergic reactions (rash, swelling, or anaphylaxis)

Discontinue use immediately if serious side effects occur.

Drug Interactions

Use with caution alongside:

• Diuretics (e.g., furosemide)
• Other aminoglycosides or nephrotoxic drugs
• Neuromuscular blocking agents
• Penicillins (if mixed in the same solution, may cause inactivation)

Storage Instructions

• Store below 25°C in a dry place
• Protect from light
• Do not freeze
• Keep out of reach of children
• Use immediately once opened

Note: Nebcin Injection should only be administered by or under the supervision of a qualified healthcare professional. Blood levels, renal function, and auditory function should be monitored during prolonged therapy.