PENCITAL 2.25mg INJ

Description

Generic Name: Piperacillin Sodium + Tazobactam Sodium
Brand Name: PENCITAL
Strength: 2.25g (2g Piperacillin + 0.25g Tazobactam)
Form: Lyophilized powder for injection
Route of Administration: Intravenous (IV)
Pharmacological Class: Broad-Spectrum Penicillin Antibiotic with β-lactamase Inhibitor
Prescription Status: Prescription-only (Rx)

Overview:

PENCITAL 2.25g Injection is a broad-spectrum antibacterial agent that combines Piperacillin, a potent extended-spectrum penicillin, with Tazobactam, a β-lactamase inhibitor. This combination enhances the antibiotic activity of piperacillin by protecting it from degradation by β-lactamase enzymes produced by resistant bacteria.

It is widely used for treating moderate to severe infections, including hospital-acquired infections, and is particularly effective against Gram-positive, Gram-negative, and anaerobic bacteria.

Mechanism of Action:

• Piperacillin interferes with bacterial cell wall synthesis, leading to cell lysis and death.
• Tazobactam inhibits β-lactamase enzymes that would otherwise break down piperacillin, thereby extending its antibacterial spectrum, especially against resistant strains.

Indications:

PENCITAL 2.25g is indicated for the treatment of:

• Lower respiratory tract infections (e.g., pneumonia)
• Urinary tract infections (UTIs)
• Intra-abdominal infections
• Skin and soft tissue infections
• Gynecological infections
• Septicemia (bloodstream infections)
• Bone and joint infections
• Hospital-acquired and ventilator-associated infections

Dosage and Administration:

• Typical adult dose: 2.25g every 6–8 hours by slow intravenous infusion over 20–30 minutes
• Dosage may be adjusted based on the type and severity of infection, renal function, and patient response
• Not for intramuscular use
• Must be reconstituted and diluted before use

Always to be administered under the supervision of a healthcare professional.

Side Effects:

Common:

• Diarrhea
• Nausea
• Rash
• Injection site reactions

Less common but serious:

• Allergic reactions (anaphylaxis)
• Blood disorders (e.g., leukopenia, thrombocytopenia)
• Hepatic enzyme elevation
• Clostridium difficile-associated diarrhea

Precautions:

• Use with caution in patients with:
  • Renal impairment (dose adjustment required)
  • History of penicillin allergy or hypersensitivity to β-lactams
• Monitor renal function, liver enzymes, and complete blood counts during prolonged therapy
• Prolonged use may result in superinfections, including fungal overgrowth

Drug Interactions:

• May increase the nephrotoxicity of aminoglycosides
• May reduce efficacy of oral contraceptives
• Concurrent use with anticoagulants may increase bleeding risk
• Should not be mixed with other drugs in the same IV line unless compatibility is confirmed

Storage Instructions:

• Store vials in a cool, dry place below 25°C
• Reconstituted solution should be used within the recommended time frame
• Protect from light and moisture
• Keep out of reach of children

Packaging:

• Supplied as a single-use vial containing lyophilized powder
• Requires dilution and reconstitution before IV infusion

Key Benefits:

• Broad-spectrum coverage, including resistant strains
• Combines powerful antibiotic activity with enzyme inhibition
• Widely used in hospitals for serious and life-threatening infections
• Trusted in ICUs, surgical wards, and emergency care