PRALZO 0.5mg TAB 30s

Description

Generic Name: Alprazolam
Brand Name: PRALZO
Strength: 0.5mg per tablet
Form: Oral tablet
Pack Size: 30 tablets per bottle
Pharmacological Class: Benzodiazepine
Prescription Status: Prescription-only (Rx)

Overview:

PRALZO 0.5mg Tablet contains Alprazolam, a short-acting benzodiazepine, primarily used to treat anxiety disorders, panic disorders, and generalized anxiety. Alprazolam works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which has a calming effect on the nervous system. This helps in reducing feelings of anxiety, tension, and agitation.

PRALZO is commonly prescribed for the short-term relief of anxiety symptoms or as part of a long-term management plan for generalized anxiety disorder (GAD) and panic attacks. Due to its sedative and relaxing properties, it is highly effective in reducing anxiety-related symptoms and helping patients return to a more stable emotional state.

Mechanism of Action:

Alprazolam works by enhancing the action of GABA, a naturally occurring inhibitory neurotransmitter that reduces neural excitability in the central nervous system (CNS). By binding to benzodiazepine receptors, it increases the affinity of GABA for its receptors, leading to CNS depression, resulting in calming effects and reduced anxiety levels.

Indications:

• Generalized Anxiety Disorder (GAD)
• Panic Disorder (with or without agoraphobia)
• Short-term relief of severe anxiety symptoms
• Anxiety associated with depression
• Situational anxiety, including anxiety before medical procedures

Dosage and Administration:

• Adults:
  • Initial dose: 0.25mg to 0.5mg taken 2–3 times daily
  • Maintenance dose: Typically, 0.5mg to 4mg per day depending on the severity of symptoms, divided into multiple doses.
  • Adjust the dose based on individual patient response.
• Elderly or those with liver impairment: Start at the lowest possible dose (e.g., 0.25mg) to reduce the risk of side effects.

It’s important to follow the prescribed dosage and consult a healthcare provider before changing the dose.

Side Effects:

Common:

• Drowsiness
• Dizziness
• Lightheadedness
• Dry mouth
• Blurred vision
• Weight changes

Less common but serious:

• Memory impairment
• Confusion
• Slurred speech
• Impaired coordination
• Increased risk of falls (especially in elderly patients)

Serious allergic reactions (rare):

• Rash, itching, swelling, difficulty breathing

Precautions:

• Dependence and Withdrawal: Alprazolam is habit-forming, and long-term use may lead to physical and psychological dependence. Gradual tapering of the dose is recommended when discontinuing.
• Pregnancy: Use during pregnancy should only occur if clearly needed, as it may pose a risk to the fetus.
• Liver or Kidney Impairment: Dose adjustments are necessary in patients with hepatic or renal insufficiency.
• Avoid Alcohol: Combining Alprazolam with alcohol can increase the risk of severe side effects, including respiratory depression and sedation.

Drug Interactions:

• CNS depressants (e.g., alcohol, barbiturates, opioids) may increase the sedative effect, leading to respiratory depression, coma, or even death.
• Antidepressants: Use caution when combining with SSRIs, SNRIs, or other medications used to treat mood disorders, as it may increase the sedative effect.
• Cimetidine, ketoconazole, and other CYP3A4 inhibitors may increase alprazolam blood levels, requiring a reduction in dose.

Storage Instructions:

• Store at room temperature (15°C to 25°C).
• Keep away from light and moisture.
• Keep out of reach of children.

Packaging:

• Supplied as 30 tablets in a sealed bottle
• Each tablet contains 0.5mg of Alprazolam

Key Benefits:

• Effective in relieving acute anxiety and preventing panic attacks
• Provides rapid onset of action, usually within 30–60 minutes
• Well-tolerated for short-term and long-term use under medical supervision
• Low dose options allow for personalized treatment
• Oral tablet form makes it convenient for home use