Description
ROMERO 500mg Injection is a sterile, intravenous formulation of meropenem, a broad-spectrum carbapenem antibiotic manufactured by Sami Pharmaceuticals. It is designed for the treatment of serious bacterial infections in hospitalized patients, particularly those caused by multi-drug-resistant organisms.
🩺 Indications
ROMERO 500mg Injection is indicated for the treatment of:
- Hospital- and ventilator-associated pneumonia
- Bronchopulmonary infections in cystic fibrosis
- Complicated urinary tract infections (UTIs)
- Complicated intra-abdominal infections
- Skin and soft tissue infections
- Acute bacterial meningitis
- Intra- and postpartum infections
- Management of febrile neutropenic patients
These infections are typically caused by a wide range of susceptible Gram-positive, Gram-negative, and anaerobic bacteria.
⚙️ Mechanism of Action
Meropenem works by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins (PBPs), leading to bacterial cell death. It is highly resistant to degradation by most β-lactamases, including extended-spectrum β-lactamases (ESBLs), making it effective against resistant organisms. Unlike imipenem, meropenem does not require co-administration with cilastatin, as it is stable to dehydropeptidase-
💉 Administration
ROMERO 500mg Injection is administered intravenously as an infusion. The dosage and duration of treatment depend on the type and severity of the infection, as well as the patient’s renal function. It is essential to follow the specific dosing regimen prescribed by a healthcare professional.
⚠️ Side Effects
Common side effects may include:
- Headache
- Nausea or vomiting
- Diarrhea
- Pain or inflammation at the injection site
Serious side effects are rare but may include:
- Seizures
- Severe allergic reactions (e.g., anaphylaxis)
- Clostridioides difficile-associated diarrhea
- Elevated liver enzymes
- Renal dysfunction
Patients should be monitored for these adverse effects during therapy.
🛡️ Precautions
Before using ROMERO 500mg Injection, inform your healthcare provider if you have:
- A history of seizures
- Renal impairment
- Allergies to meropenem or other β-lactam antibiotics
- Gastrointestinal disorders, such as colitis
Caution is advised when administering meropenem to patients with these conditions.
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