Description
Ivabradine is a unique heart rate-lowering agent that works by targeting the If current in the sodium-gated channels in cardiac myocytes. It reduces the heart rate through a different mechanism of action than traditional heart rate lowering agents, such as beta-blockers or calcium channel blockers. Ivabradine is a selective If current inhibitor, meaning it selectively targets the If component of the cardiac sodium-gated channels, which is decreasing its availability during the cardiac action potential.
Ingredients
Ivabradine
Drug Class
Hyperpolarization-Activated Cyclic Nucleotide-Gated (Hcn) Channel Blockers
Uses
Ivabradine is utilized for the following therapeutic indications:
- Management of chronic stable angina pectoris in patients with normal sinus rhythm
- Treatment of heart failure with reduced ejection fraction
- Used to reduce the risk of hospitalization for worsening heart failure
- Effective in patients who cannot tolerate beta-blockers or in addition to beta-blocker therapy
Reviews
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