Description
Description
Phloroglucinol and trimethylphloroglucinol are spasmolytic agents that act directly on smooth muscle to relieve spasms. They inhibit phosphodiesterase, leading to increased intracellular cAMP levels, which promotes smooth muscle relaxation. This mechanism helps in reducing intestinal and biliary spasms, making them effective in treating certain gastrointestinal disorders.
Ingredients
Phloroglucinol, trimethylphloroglucinol
Drug Class
Antispasmodic agent
Dosage Form
Injection
Uses
The following are the uses of Phloroglucinol, trimethylphloroglucinol injection:
Used for treating spasms and pain in the biliary and urinary tracts, as well as smooth muscle disorders.
Used for relieving symptoms of renal colic and biliary colic.
Used for relaxing the sphincter of Oddi and reducing biliary pressure.
Used for treating ureteral spasms associated with ureteral stones.
Used for facilitating the passage of gallstones and kidney stones.
Used for managing esophageal and gastrointestinal spasms.
Used for diagnostic purposes to assess biliary and pancreatic function.
Dosage
To be used as per doctor’s prescription
In case of Overdose
In the case of an overdose of Phloroglucinol, trimethylphloroglucinol injection, the following symptoms may occur severe gastrointestinal disturbances, including nausea, vomiting, and diarrhea, along with possible central nervous system effects such as dizziness, headache, and confusion. In severe cases, there may be a rapid decrease in blood pressure, leading to shock. Prompt medical attention is necessary, including supportive care and monitoring of vital signs to manage the potential complications effectively.
Missed Dose
In the case of a missed dose of Phloroglucinol, trimethylphloroglucinol injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume the medication.
How To Use
To administer the Phloroglucinol, trimethylphloroglucinol injection, clean the injection site with an alcohol swab, insert the needle subcutaneously or intramuscularly as directed by your healthcare professional, inject the prescribed dose slowly, and gently press a dry cotton ball over the injection site after withdrawal to prevent any leakage.
When Not to Use
Here are the situations when Phloroglucinol and trimethylphloroglucinol injection should not be used:
Should not be administered to individuals with a known allergy or hypersensitivity to Phloroglucinol, trimethylphloroglucinol, or any other components of the injection.
Contraindicated in patients with a history of severe adverse reactions to similar medications.
Not recommended for individuals with a history of kidney disease or impaired kidney function.
Should not be used in patients with severe liver impairment or active liver disease.
Contraindicated during pregnancy, especially in the first trimester, due to potential risks to fetal development.
Not suitable for breastfeeding mothers as it may pass into breast milk and harm the nursing infant.
Should be avoided in patients with a history of gastrointestinal obstruction or perforation.
Not recommended for individuals with a history of severe cardiovascular disease or unstable blood pressure.
Should not be administered to patients with a history of bleeding disorders or those taking anticoagulant medications.
Side Effects
The side effects of Phloroglucinol, trimethylphloroglucinol injection may include:
Skin irritation or redness at the injection site.
Itching or hives.
Nausea and vomiting.
Dizziness or lightheadedness.
Headache.
Diarrhea.
Palpitations or increased heart rate.
In rare cases, an allergic reaction, including difficulty breathing, swelling of the face and throat, and severe dizziness.
Precautions & Warnings
Following are the precautions and warnings for Phloroglucinol, trimethylphloroglucinol injection:
It should not be administered to patients with known hypersensitivity or allergy to phloroglucinol or trimethylphloroglucinol.
This medication should be used with caution in patients with kidney or liver disease, as it may require dosage adjustments.
Intravenous administration should be performed slowly to avoid rapid changes in blood pressure.
Patients with a history of cardiovascular disease should be closely monitored, as this medication may affect blood pressure.
Not recommended for long-term use; prolonged use may lead to drug tolerance and reduced effectiveness.
Elderly patients may be more susceptible to side effects, and dosage adjustments might be necessary.
Pregnant and breastfeeding women should consult their doctor before using this medication as its safety during pregnancy and lactation is not well established.
Drug Interactions
Following are the drug interactions for Phloroglucinol, trimethylphloroglucinol injection:
It may interact with other antispasmodic medications, leading to increased risk of side effects like dizziness and blurred vision.
Monoamine oxidase inhibitors (MAOIs) should be avoided, as they can cause severe reactions including hypertension and hyperthermia.
The effect of anticoagulants may be enhanced, increasing the risk of bleeding. Close monitoring is necessary.
Concomitant use with sedatives or central nervous system (CNS) depressants can potentiate their effects, causing excessive drowsiness.
Nonsteroidal anti-inflammatory drugs (NSAIDs) might decrease the efficacy of Phloroglucinol, trimethylphloroglucinol injection.
It may interact with drugs metabolized by the liver, potentially altering their blood levels.
Anticonvulsants may have reduced effectiveness when used with this injection.
Trimethylphloroglucinol may increase the risk of adverse effects when taken with other drugs having similar actions.
Food Interactions
Following are the food interactions for Phloroglucinol, trimethylphloroglucinol injection:
Avoid consuming grapefruit and grapefruit juice as they may interfere with the medication’s metabolism, potentially leading to increased side effects.
Alcohol consumption should be limited or avoided as it can increase the risk of gastrointestinal issues and may enhance the sedative effects of the medication.
High-fat meals might delay the absorption of the medication, affecting its effectiveness.
Caffeinated beverages like coffee and energy drinks should be consumed in moderation as they may exacerbate anxiety or nervousness.
Avoid spicy foods as they can irritate the gastrointestinal tract and potentially worsen symptoms.
Stay well-hydrated and ensure adequate fluid intake to support the body’s natural processes and aid in the medication’s distribution.
Consider a balanced diet rich in fiber to promote digestive health and minimize the risk of gastrointestinal side effects.
Always consult your healthcare provider for personalized advice regarding dietary considerations and potential food interactions.
Storage/Disposal
Phloroglucinol, trimethylphloroglucinol injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), away from excessive heat, moisture, and direct sunlight. It is crucial to keep the injection in its original packaging, ensuring the seal remains intact until use. When disposing of the medication, do not throw it into the trash or pour it down the drain. Instead, utilize designated pharmaceutical waste disposal programs or follow local guidelines for safe disposal. Always exercise caution to prevent accidental exposure or ingestion, especially by children and pets.
Control Drug
No
Quick Tips, if any
Following are the quick tips for Phloroglucinol, trimethylphloroglucinol injection:
Ensure the injection is administered by a trained healthcare professional for safety and accuracy.
Verify the correct dosage and injection site as prescribed by your doctor.
Relax and breathe comfortably during the injection to ease any anxiety.
Report any unusual pain, swelling, or redness at the injection site to your healthcare provider.
Dispose of used needles and syringes safely in designated sharps containers.
Avoid missing doses to maintain consistent therapeutic levels.
Store the medication as directed, away from direct sunlight and moisture.
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