Vancomycin Injection 500 mg 1 Vial

Description

Product Name:

Vancomycin Injection 500 mg

Pack Size:

1 Vial (500 mg per vial)

Generic Name:

Vancomycin Hydrochloride

Pharmacological Class:

Glycopeptide Antibiotic

Product Description:

Vancomycin Injection 500 mg is a sterile, bactericidal antibiotic used intravenously for the treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and other resistant strains. It is often reserved for infections that are resistant to other antibiotics, making it a critical agent in hospital and clinical settings.

The vial contains 500 mg of vancomycin hydrochloride powder, which must be reconstituted with an appropriate diluent before intravenous infusion.

Indications / Uses:

Vancomycin Injection is indicated for the treatment of:

• Serious infections caused by MRSA
• Severe infections caused by susceptible Gram-positive bacteria, including Staphylococcus aureus and Streptococcus species
• Endocarditis, osteomyelitis, pneumonia, septicemia, and skin and soft tissue infections
• Clostridium difficile colitis (oral form is preferred, but IV form used in severe systemic infections)
• Patients allergic to beta-lactam antibiotics

Dosage and Administration:

• The dose and duration depend on the severity of infection, renal function, and patient weight.
• Typical adult dose: 15-20 mg/kg every 8-12 hours, infused intravenously over at least 60 minutes to reduce the risk of infusion-related reactions.
• Dose adjustments are necessary in patients with impaired renal function.
• The powder vial should be reconstituted with sterile water for injection or suitable diluent and then further diluted before IV administration.
• Monitor serum vancomycin levels to ensure therapeutic concentration and avoid toxicity.

Mechanism of Action:

Vancomycin inhibits bacterial cell wall synthesis by binding to the D-alanyl-D-alanine terminus of cell wall precursors, preventing cross-linking and leading to cell lysis. It is effective primarily against Gram-positive bacteria.

Side Effects:

Common:

• Red man syndrome (flushing, rash, hypotension during infusion)
• Nephrotoxicity (kidney damage)
• Ototoxicity (hearing loss)
• Phlebitis at injection site
• Fever, chills

Serious:

• Severe allergic reactions (anaphylaxis)
• Neutropenia (low white blood cells)
• Thrombocytopenia (low platelet count)

Warnings and Precautions:

• Infuse slowly (over at least 60 minutes) to avoid Red Man Syndrome
• Monitor kidney function and serum levels regularly
• Use cautiously in patients with renal impairment, hearing loss, or elderly patients
• Not for intramuscular use
• Use only under strict medical supervision

Drug Interactions:

• Increased nephrotoxicity risk with aminoglycosides, NSAIDs, or loop diuretics
• Avoid concomitant use with other ototoxic drugs if possible
• Careful monitoring required when used with neuromuscular blocking agents

Contraindications:

• Known hypersensitivity to vancomycin or formulation components
• Use with caution in patients with hypersensitivity to other glycopeptides

Storage Instructions:

• Store vial below 25°C
• Protect from light and moisture
• Keep vial in original packaging until use
• Use immediately after reconstitution or as per stability guidelines

Regulatory Classification:

• Prescription only medicine (POM)
• Hospital/clinical use

Summary:

Vancomycin Injection 500 mg is a potent glycopeptide antibiotic reserved for serious infections caused by resistant Gram-positive bacteria. It requires careful dosing and monitoring due to potential nephrotoxicity and ototoxicity. Proper infusion technique and patient monitoring are critical for safe and effective therapy.