Description
Brand Name: Vonolia
Generic Name: Vonoprazan Fumarate
Strength: 10 mg
Dosage Form: Tablet (oral use)
Drug Class: Potassium-Competitive Acid Blocker (P-CAB)
Overview:
Vonolia 10 mg contains vonoprazan fumarate, a next-generation acid suppressant used primarily for the treatment of acid-related gastrointestinal conditions. Unlike traditional proton pump inhibitors (PPIs), vonoprazan belongs to the Potassium-Competitive Acid Blocker (P-CAB) class, offering faster onset and more potent and sustained acid suppression.
Mechanism of Action:
Vonoprazan works by competitively inhibiting the potassium-binding site of the H⁺/K⁺-ATPase enzyme system in the stomach’s parietal cells. This enzyme is the final pathway for acid secretion. By blocking it directly and reversibly, vonoprazan prevents gastric acid production more effectively and rapidly than PPIs, which require activation in acidic environments and may take several days for full effect.
Indications:
Vonolia 10 mg is used for the treatment and prevention of:
- Gastroesophageal reflux disease (GERD)
- Erosive esophagitis
- Peptic ulcer disease (gastric and duodenal ulcers)
- Helicobacter pylori eradication therapy (as part of combination therapy)
- Prevention of NSAID-associated gastric ulcers
Benefits Over Traditional PPIs:
- Faster symptom relief – action begins within hours
- More consistent acid suppression
- Not affected by food intake
- No requirement for acid activation
- Potentially better results in nocturnal acid breakthrough
Dosage and Administration:
- Usual adult dose: 10 mg once daily, typically before or after meals
- H. pylori eradication: Usually part of a triple therapy regimen (vonoprazan + amoxicillin + clarithromycin or metronidazole)
Note: Dosage may vary based on indication, patient condition, and co-administered drugs.
Contraindications:
- Known hypersensitivity to vonoprazan or any tablet components
- Caution in patients with severe hepatic impairment
Adverse Effects:
Common side effects include:
- Diarrhea
- Headache
- Abdominal pain
- Nausea
- Elevated liver enzymes (less common)
Serious but rare reactions:
- Hypomagnesemia with long-term use
- Bacterial overgrowth due to hypochlorhydria
- Risk of rebound acid hypersecretion upon discontinuation
Drug Interactions:
- May affect absorption of drugs requiring acidic pH (e.g., ketoconazole, atazanavir)
- Should be used with caution in combination with antiplatelet or anticoagulant therapies
Pharmacokinetics:
- Onset: Within 1–2 hours
- Half-life: ~7–9 hours
- Metabolism: Primarily via liver (CYP3A4)
- Excretion: Mostly fecal
Storage:
- Store below 30°C (86°F)
- Keep away from moisture and direct sunlight
- Keep out of reach of children
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