Description
Zoloft Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Sertraline HCl
Used For
Depression
How it works
Sertraline potentiates serotonergic activity in the central nervous system through inhibition of neuronal reuptake of serotonin (5-HT).
Zoloft Tablets Usage And Safety
Dosage
Sertraline HCl
Side Effects
Hypersensitivity reactions to sertraline , Disulfiram-alcohol reaction when ZOLOFT oral solution is taken with disulfiram , QT prolongation and ventricular arrhythmias when taken with pimozide , Suicidal thoughts and behaviors , Serotonin syndrome , Increased risk of bleeding , Activation of mania/hypomania , Discontinuation syndrome , Seizures , Angle-closure glaucoma , Hyponatremia.
Drug Interactions
Selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue , other SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John’s Wort, aspirin, clopidogrel, heparin, warfarin , propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, thoridazine, tolterodine, venlafaxine , fosphenytoin .
Indication
Sertraline HCl is indicated for the treatment of the following *Major depressive disorder (MDD) * Obsessive-compulsive disorder (OCD) * Panic disorder (PD)
When not to Use
It is contraindicated in patients:-Taking, or within 14 days of stopping, MAOIs, (including the MAOIs linezolid and intravenous methylene blue) because of an increased risk of serotonin syndrome.- Taking pimozide- With known hypersensitivity to sertraline (e.g., anaphylaxis, angioedema).
Zoloft Tablets Precautions
Precaution
Exposure to SSRIs and SNRIs, including sertraline HCl in late pregnancy may lead to an increased risk for neonatal complications requiring prolonged hospitalization, respiratory support, and tube feeding, and/or persistent pulmonary hypertension of the newborn (PPHN).
Zoloft Tablets Warnings
Warning 1
Serotonin-norepinephrine reuptake inhibitors (SNRIs) and SSRIs, including sertraline HCl , can precipitate serotonin syndrome, a potentially life-threatening condition .
Warning 2
Drugs that interfere with serotonin reuptake inhibition, including sertraline HCl, increase the risk of bleeding events. Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may add to this risk.
Warning 3
Hyponatremia may occur as a result of treatment with SNRIs and SSRIs, including sertraline HCl. Cases with serum sodium lower than 110 mmol/L have been reported .
Zoloft Tablets Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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