Arcenate 120mg im/iv Inj 1s

Description

Here is a long description for Arcenate 120 mg Injection (IM/IV):

Arcenate 120 mg Injection is a sterile antimalarial medication that contains artesunate, a potent and fast-acting derivative of artemisinin. It is used primarily for the treatment of severe malaria, particularly cases caused by Plasmodium falciparum, which can lead to life-threatening complications if not treated promptly. This higher-dose formulation is administered via intravenous (IV) or intramuscular (IM) injection and is intended for use in healthcare settings under close medical supervision.

Mechanism of Action:
Artesunate acts by generating reactive oxygen species (free radicals) within the malaria parasite, leading to oxidative stress and rapid destruction of the parasite inside red blood cells. It targets early asexual forms of the parasite, making it especially effective in severe infections.

Indications:

• Treatment of severe and complicated malaria caused by Plasmodium falciparum
• Suitable for both adults and children
• Often used as initial emergency therapy and followed by a complete course of oral antimalarials (usually artemisinin-based combination therapy)

Dosage & Administration:

• 120 mg is typically administered IV or IM, depending on the patient’s condition and clinical guidelines
• Initial dosing is usually at 0, 12, and 24 hours, followed by once-daily doses
• Final dose and duration are adjusted based on body weight, disease severity, and treatment response
• Must be reconstituted with the provided solvent immediately prior to use

Key Features:

• Rapid onset of action, critical in life-threatening malaria
• Effective against multi-drug resistant strains
• Generally well-tolerated with minimal side effects

Precautions & Monitoring:

• Monitor for delayed hemolysis, a known adverse effect of artesunate
• Regular assessment of renal and liver function, hemoglobin levels, and vital signs during treatment
• Not recommended as monotherapy for uncomplicated malaria

Storage:

• Store below 25°C, away from light
• Comes as a lyophilized powder to be mixed with sterile solvent before administration