Description
Description
Cefixime 400mg capsules exhibit their antibacterial activity through a specific mechanism of action. Cefixime primarily inhibits bacterial cell wall synthesis by binding to and blocking the activity of penicillin-binding proteins (PBPs), which are essential enzymes responsible for cross-linking peptidoglycan strands in the bacterial cell wall. By inhibiting PBPs, Cefixime disrupts the formation of a strong and stable cell wall, leading to weakened bacterial cell structure and ultimately cell lysis. This mechanism is particularly effective against susceptible bacteria, as it interferes with a vital process required for their growth and survival.
Ingredients
Cefixime 400mg
Drug Class
Cephalosporin antibiotic
Dosage Form
Capsule
Uses
The following are the uses of Cefixime 400mg Capsule:
Used for treating bacterial infections, particularly those caused by susceptible bacteria.
Used for respiratory tract infections like pneumonia and bronchitis.
Used for treating urinary tract infections, effectively eliminating bacteria.
Used for skin and soft tissue infections, promoting healing.
Used for bone and joint infections, providing targeted treatment.
Used for preventing and controlling infections during surgery.
Used for managing severe infections that require high-dose antibiotics.
Dosage
Dose must be taken according to doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult dose (For chronic bronchitis, otitis media, gonorrhea, urinary tract infection): 400mg daily divided dose every 12 to 24 hours. Pediatric dose (For Chronic Bronchitis, Otitis media, Pharyngitis, Tonsillitis, Gonorrhea, Urinary tract infection): Children of age 6 months to 12 years, body weight is not more than 45kg; then take 8mg/kg/day in single dose or in divided doses after 12 hours. For 12 years above age: weight is more than 45kg; then take 400mg once.
In case of Overdose
In the case of an overdose of Cefixime 400mg Capsules, it is important to recognize the signs and symptoms, which may include nausea, vomiting, diarrhea, and abdominal pain. If an overdose is suspected, seek medical advice promptly. Treatment may involve monitoring and supportive care, ensuring the patient’s vital signs are stable and managing any adverse effects. Quick action can help prevent potential complications and ensure the best possible outcome. Always keep medications out of reach of children to prevent accidental ingestion.
Missed Dose
In the case of a missed dose of Cefixime 400mg Capsule, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to resume your medication safely. Always consult your doctor or pharmacist if you are unsure about how to manage missed doses.
How To Use
To take Cefixime 400mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, either with or without food, as directed by your healthcare professional.
When Not to Use
Here are the circumstances where Cefixime 400mg Capsule should not be administered:
Avoid use in individuals with a known allergy to Cefixime or other cephalosporin antibiotics.
Not suitable for patients with a history of severe gastrointestinal diseases, especially colitis.
Contraindicated in patients with severe kidney impairment or kidney failure.
Do not administer to patients with a history of severe allergic reactions to any medication.
Should not be used in infants below 6 months of age due to potential risks.
Side Effects
The side effects of Cefixime 400mg Capsule may include:
Diarrhea
Nausea and vomiting
Abdominal pain
Skin rash or itching
Headache
Dizziness
Vaginal yeast infection
Fatigue
Precautions & Warnings
Following are the precautions and warnings for Cefixime 400mg Capsule:
Do not take this medication if you are allergic to Cefixime or any other cephalosporin antibiotics.
Cefixime should be used with caution in patients with kidney disease or impairment, as dosage adjustments may be necessary.
Inform your doctor if you have a history of gastrointestinal diseases as it may cause diarrhea, and in rare cases, Clostridium difficile-associated diarrhea.
This medication may decrease the effectiveness of hormonal birth control methods, so it is advised to use alternative contraception during treatment.
Elderly patients may be more susceptible to the side effects of Cefixime, hence regular monitoring is required.
Cefixime should be used with caution during pregnancy and breastfeeding, only if the potential benefits outweigh the risks.
Avoid alcohol consumption while taking Cefixime as it may increase the risk of certain side effects.
Drug Interactions
Following are the drug interactions for Cefixime 400mg Capsule:
Probenecid can decrease the renal excretion of cefixime, potentially leading to increased plasma concentrations.
Concurrent use with other nephrotoxic drugs may increase the risk of renal toxicity.
Cefixime may reduce the effectiveness of oral contraceptives, so additional contraceptive measures are recommended.
The absorption of Cefixime can be decreased by antacids containing aluminum and magnesium hydroxide, as well as iron-containing preparations.
May increase the risk of bleeding when taken with anticoagulants, such as warfarin.
Cefixime can potentially affect the metabolism of drugs metabolized by the liver, including certain antiepileptic medications.
Concurrent use with other antibiotics, such as aminoglycosides, may increase the risk of adverse effects on the kidneys and hearing.
Food Interactions
Following are the food interactions for Cefixime 400mg Capsule:
Avoid consuming alcohol with this medication as it may reduce the absorption of Cefixime, decreasing its effectiveness.
Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Cefixime in the blood, potentially leading to an increased risk of side effects.
Dairy products like milk, yogurt, and cheese should be separated from the medication as they can decrease the absorption of Cefixime. Take the medicine at least 2 hours before or after consuming dairy.
High-fat meals can delay the absorption of Cefixime, so it is best to take the medicine on an empty stomach.
Avoid caffeine-rich foods and beverages as they may increase the elimination of Cefixime, reducing its effectiveness.
Vitamin C supplements or citrus fruits may decrease the absorption of Cefixime, so it’s best to separate their consumption by a few hours.
Avoid iron-rich foods or supplements as they can decrease the absorption of Cefixime. Take the medicine at least 2 hours before or after consuming iron supplements.
Probiotics and fermented foods should be consumed with caution as they may decrease the effectiveness of Cefixime by altering the gut flora.
Storage/Disposal
Cefixime 400mg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct exposure to sunlight and moisture. Keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to store it away from heat sources like heaters or ovens, as temperature fluctuations can impact its effectiveness. Dispose of any unused or expired capsules responsibly; do not flush them or pour them down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods. Always keep medications out of children’s reach to prevent accidental consumption.
Quick Tips, if any
Following are the quick tips for Cefixime 400mg Capsule:
Swallow the capsule whole with a full glass of water; do not crush, chew, or break it.
Take the capsule with or without food as directed by your doctor.
Maintain a consistent daily dose to ensure effective treatment.
Avoid missing doses; take it at the same time each day to establish a routine.
Complete the full course of medication as prescribed, even if you feel better earlier.
Store the capsules in a cool, dry place, away from direct sunlight and moisture.
Inform your doctor if you have any allergies or medical conditions before taking this medication.
Laboratory Screening
To confirm microbial infections, go for; Blood Culture Test. In order to confirm typhoid fever, go for; TyphiDot (IgM) Test. To monitor kidney function along with the use of this medicine, go for; Renal Function Test. To monitor the risks for anemia along with use of this medicine, go for; CBC blood test.
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