Description
Description
Gliclazide is a medication used to treat adults with type 2 diabetes. It helps restore your body’s response to insulin, thereby lowering your chances of developing serious diabetes complications. Moreover, it reduces blood sugar levels. However, the medication doesn’t treat low blood sugar (hypoglycemia) or type 1 diabetes or diabetic ketoacidosis. Gliclazide is a second-generation sulfonylurea drug existing in two enantiomers. It binds to specific sulfonylurea receptors on the beta cell surface, leading to the closure of the ATP-sensitive potassium channel. Consequently, this triggers intracellular calcium influx and inhibits potassium efflux, causing the secretion of insulin.
Ingredients
Gliclazide
Drug Class
Sulfonylurea
Dosage Form
Tablet
Uses
Unveiling its multifaceted uses and transformative applications as follows:
Used to treat diabetes mellitus
Gliclazide is a second-generation oral anti diabetic drug
Used in conjunction with diet and exercise in the treatment of type 2 diabetes
Not first line therapy
Gliclazide is a rapid- and short-acting oral hypoglycemic agent used to treat insulin-independent diabetes mellitus
Mechanism of action involves inhibition of pancreatic alpha cells and stimulation of pancreatic beta cells
Dosage
Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:
Diabetes Type 2- Initially, 80mg daily (40mg in the morning and 40mg in the evening)
Diabetes Type 2 (Elderly)- Initially, 40mg daily (20mg in the morning and 20mg in the evening)
Diabetes Type 2 (Child)- Initially, 0.2mg/kg body weight daily in 1 or 2 doses
In case of Overdose
An overdose of Gliclazide can lead to hypoglycemia, which is a condition characterized by low blood sugar levels in the body. This can lead to several symptoms such as feeling shaky, sweating, fast-paced heartbeat, blurred vision, and anxiety. These symptoms can worsen and lead to a loss of consciousness if left untreated. Some ways to treat this include eating or drinking something that contains sugar, such as orange juice or a candy, to help stabilize the blood sugar levels. A person suffering from an overdose should be alert and awake to safely consume some sugar-containing products. If they are not, it is necessary to seek emergency medical care right away for further intervention. If you would like further information on the potential risks associated with this medication, please specify and I will be happy to provide it.
Missed Dose
If you happen to miss a dose of Gliclazide B.P. 80mg, take it as soon as possible. However, if it is almost time for your next dose, it is recommended to skip the missed dose and resume your regular dosage schedule. This is to avoid doubling the dose, which could lead to an overdose. It is crucial to maintain a regular dosing schedule to ensure that the medication works effectively and to minimize any potential adverse effects. If you have any questions or concerns about your medication, it is advised to consult with your healthcare provider or pharmacist for further guidance and clarification.
How To Use
Before you begin taking Gliclazide B.P. 80mg, it is important to thoroughly read through the provided prescription information and any warning labels on the packaging. This medication contains the active ingredient gliclazide, a sulfonylurea, which helps stimulate the pancreas to produce insulin in the body. It is specifically used to treat adults with type 2 diabetes when diet and exercise alone do not adequately control blood sugar levels. To take the Gliclazide B.P. 80mg tablets, you should follow these directions:
When Not to Use
Discerning instances where this medication may not be appropriate:
If you experience low blood sugar, wait until symptoms resolve before taking Gliclazide B.P. 80mg and keep sugar supplements on hand for future episodes.
Consult your doctor before taking Gliclazide B.P. 80mg if you have acute conditions like fever, infection, or illness as it alters your glucose tolerance and insulin needs.
If you experience gastrointestinal disturbances such as nausea, vomiting, and diarrhea, consider waiting until these symptoms subside before taking Gliclazide B.P. 80mg and speak with your doctor or pharmacist to assess the benefits versus side effects.
Gliclazide B.P. 80mg may lead to harmful increases in potassium levels in the blood if you have concussion or severe head trauma.
Side Effects
Unraveling the side effects lurking behind this medications are as follows:
Excessive thirst
Frequent urination
Blurred vision
Tiredness
I nflammation of the mouth
Runny or stuffy nose
Chronic fatigue
Precautions & Warnings
Patients should use caution and consult a healthcare provider in the following situations:
Risk factors for hypoglycemia, such as malnutrition, severe or poorly compensated endocrine disorders, or severe vascular disease.
G6PD deficiency or porphyria.
Stress-related states, including severe trauma, fever, infection, or surgery.
Mild to moderate hepatic or renal impairment.
Elderly individuals.
Drug Interactions
Drug interactions with gliclazide include:
Insulin (may increase risk of hypoglycemia- monitor blood glucose levels closely)
Other antidiabetic agents (e.g., metformin) (may increase risk of hypoglycemia- adjust doses as needed)
CYP2C19 inhibitors (e.g., omeprazole) (may increase gliclazide levels- monitor for increased hypoglycemia)
CYP3A4 inhibitors (e.g., ketoconazole) (may increase gliclazide levels- monitor for increased hypoglycemia)
Diuretics (e.g., furosemide) (may alter blood glucose levels- monitor blood glucose levels closely)
Corticosteroids (e.g., prednisone) (may increase blood glucose levels- monitor blood glucose levels closely)
Beta-blockers (e.g., propranolol) (may mask symptoms of hypoglycemia- monitor blood glucose levels closely)
Alcohol (may enhance or diminish hypoglycemic effects- monitor blood glucose levels closely)
Anticoagulants (e.g., warfarin) (may alter bleeding risk- monitor INR closely)
Storage/Disposal
Gliclazide is an oral anti-diabetic drug used to treat Type 2 diabetes. It works by stimulating insulin release from the pancreas and it is available in tablet form with 80mg or 160mg strength. It is important to follow the dosage instructions on product packaging or as advised by your physician for safe and effective use. To store Gliclazide B.P. 80mg, you should:
Laboratory Screening
Glyclazide is a medication used to treat type 2 diabetes, and its dosage is tailored to each patient’s response and blood sugar levels. To achieve the best results and identify any issues that may require attention, it is essential to monitor your blood sugar levels and undergo regular laboratory tests while taking this medication. These tests allow your healthcare provider to assess how well the medication is working and ensure it is safe for you to take. They also help detect any complications arising from the condition or the medication itself. Specifically, there are several tests that you should undergo to assess your overall health and monitor for complications:
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