Description
Description
Dinoprostone is a prostaglandin that functions through a multi-step mechanism of action. First, it stimulates cervical ripening by promoting collagenase activity and increasing water content in the cervical tissue. This leads to softening and dilation of the cervix, facilitating labor. Additionally, dinoprostone induces uterine contractions by acting on the myometrium, enhancing the effectiveness of labor induction. It is particularly used in obstetrics for the induction of labor and for the management of missed or incomplete abortion.
Ingredients
Dinoprostone
Drug Class
Prostaglandin analog
Dosage Form
Tablet
Uses
Dinoprostone is used to prepare the cervix for the induction of labor in pregnant women who are at or near term. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Dosage
Dinoprostone dosage for the indication of labor induction, with a single dose:
Adults – 3 mg tablet for induction of labor.
Children – Not recommended.
In case of Overdose
Overdose can cause excessive uterine contractions or gastrointestinal symptoms. Seek medical assistance immediately.
Missed Dose
If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.
How To Use
Administered intravaginally for induction of labor or cervical ripening. Follow healthcare provider’s instructions closely.
When Not to Use
Dinoprostone should not be used if:
Hypersensitivity
Active pelvic inflammatory disease
History of uterine surgery
Severe uterine contractions
Side Effects
Nausea, vomiting, diarrhea, fever, chills, abdominal pain, flushing, and dizziness may occur.
Precautions & Warnings
Patient w/ compromised uteri, asthma, glaucoma, raised intraocular pressure should consult doctor
Drug Interactions
The drug interactions with dinoprostone include:
Oxytocin – Concurrent use can enhance uterine stimulation and risk of uterine hyperstimulation.
Other Uterotonics – Can increase the risk of uterine contractions and complications.
Food Interactions
For Dinoprostone, food interactions that should be considered are:
No significant interactions with food.
It is often administered in a clinical setting.
Storage/Disposal
Dinoprostone should be stored in a refrigerator (2°C to 8°C) and protected from light. It should not be frozen. Dispose of any unused or expired Dinoprostone as per local disposal guidelines or use a drug take-back program.
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