Description
Kreon 10,000 IU (Pancrelipase) – Detailed Description
Generic Name: Pancrelipase
Brand Name: Kreon
Strength: 10,000 IU (Lipase activity), with corresponding amounts of Amylase and Protease
Form: Delayed-release capsules (enteric-coated minimicrospheres)
Therapeutic Class: Digestive enzyme replacement therapy
Indications: Pancreatic enzyme replacement therapy (PERT) for people with exocrine pancreatic insufficiency (EPI)
What is Kreon 10,000 IU?
Kreon 10,000 IU is a pancreatic enzyme supplement used in the treatment of exocrine pancreatic insufficiency (EPI), a condition where the pancreas does not produce enough enzymes to digest food properly. This can occur in conditions such as:
- Cystic fibrosis
- Chronic pancreatitis
- Pancreatic cancer
- Pancreatic surgery or resection
- Shwachman-Diamond syndrome
Kreon contains pancrelipase, a combination of three digestive enzymes derived from porcine pancreas (pigs):
- Lipase – breaks down fats into fatty acids and glycerol
- Amylase – breaks down carbohydrates into simple sugars
- Protease – breaks down proteins into peptides and amino acids
Mechanism of Action
Kreon capsules contain enteric-coated minimicrospheres to ensure the enzymes survive stomach acid and release in the small intestine, where digestion occurs. This formulation closely mimics natural enzyme release and improves the digestion of fats, proteins, and carbohydrates.
Dosage and Administration
- Individualized dosing based on weight, diet, and severity of enzyme insufficiency.
- Typically taken with every meal and snack.
- Capsules should be swallowed whole with fluid; do not crush or chew (to preserve enteric coating).
- For patients unable to swallow capsules, the contents can be sprinkled on acidic soft food (e.g., applesauce) and consumed immediately.
Kreon 10,000 IU contains:
- Lipase: 10,000 IU
- Amylase: ~8,000–9,000 IU
- Protease: ~600 IU
Side Effects
Common side effects:
- Abdominal pain
- Nausea
- Bloating
- Diarrhea or constipation
Rare but serious:
- Fibrosing colonopathy (associated with very high doses)
- Hypersensitivity or allergic reactions (due to porcine origin)
Precautions
- Not for use in patients with known hypersensitivity to porcine proteins.
- Use with caution in gout, renal impairment, or hyperuricemia, due to purine content in pancrelipase.
- Monitor for signs of fibrosing colonopathy, especially in children on high doses.
Storage
- Store at room temperature (15–25°C or 59–77°F).
- Protect from moisture and do not store in humid areas (e.g., bathroom).
- Keep in original packaging until use.
Availability
Kreon is available in multiple strengths (e.g., 10,000 IU, 25,000 IU, 40,000 IU), allowing for flexible dosing based on patient needs.
Conclusion
Kreon 10,000 IU is a critical therapy for managing EPI, ensuring adequate digestion and nutrient absorption. Its special enteric-coated formulation protects enzymes from gastric acid, allowing them to act effectively in the small intestine. Proper dosing and patient education are essential for optimal results and minimizing side effects.
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