ONTIV 4mg INJ

Description

Generic Name: Ondansetron Hydrochloride
Brand Name: ONTIV
Strength: 4 mg/2 mL (commonly 2 mg/mL per ampoule)
Form: Injectable solution
Route of Administration: Intravenous (IV) / Intramuscular (IM)
Pharmacological Class: 5-HT₃ Receptor Antagonist (Antiemetic)
Prescription Status: Prescription-only (Rx)

Overview:

ONTIV 4mg Injection contains Ondansetron Hydrochloride, a selective 5-HT₃ receptor antagonist used to prevent and treat nausea and vomiting due to chemotherapy, radiotherapy, surgery, or other medical conditions. Administered via IV or IM, this injectable form provides fast and effective control of symptoms, particularly in acute care or hospital settings.

It is widely used in oncology, anesthesiology, and emergency medicine due to its rapid onset of action, excellent safety profile, and minimal sedative effects.

Mechanism of Action:

Ondansetron blocks serotonin (5-HT₃) receptors both in the central nervous system (CNS)—specifically in the chemoreceptor trigger zone (CTZ) of the brain—and in the gastrointestinal tract, where serotonin is released during chemotherapy, surgery, or illness. By blocking these receptors, it prevents the vomiting reflex.

Indications:

• Prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)
• Radiotherapy-induced nausea and vomiting
• Postoperative nausea and vomiting (PONV)
• Acute nausea/vomiting in emergency settings
• Suitable for patients who cannot tolerate oral medication

Dosage and Administration:

• IV/IM use only under medical supervision
• Typical adult dose: 4 mg injected immediately before chemotherapy or surgery
• May be repeated or followed with oral doses depending on the clinical need
• Must be administered slowly if given IV to avoid adverse cardiovascular effects

Dosage may be adjusted based on patient weight, age, and clinical response.

Common Side Effects:

• Headache
• Fatigue
• Constipation
• Injection site reactions
• Rare but serious: QT interval prolongation, bradycardia, allergic reactions

Precautions:

• Use with caution in patients with cardiac arrhythmias, electrolyte imbalances, or QT prolongation
• Monitor ECG in high-risk patients
• Use with caution in pregnant or lactating women; consult healthcare provider
• Not recommended for children under 6 months without physician supervision

Drug Interactions:

• Increased risk of QT prolongation with antiarrhythmics, antipsychotics, or other serotonergic drugs
• May reduce the effectiveness of anticonvulsants like phenytoin and carbamazepine
• Use caution when co-administered with tramadol, as it may reduce analgesic effect

Storage Instructions:

• Store below 25°C
• Protect from light
• Do not freeze
• Keep out of reach of children

Packaging:

• Available in 2 mL ampoules or vials, each containing 4 mg Ondansetron
• Sterile, single-use only

Key Benefits:

• Rapid relief of nausea and vomiting
• Useful in patients who cannot take oral medications
• Broadly used across oncology, surgery, and emergency care
• Well-tolerated with minimal sedation