Description
Panadol Cf Specification
Requires Prescription (YES/NO)
No
Generics
Paracetamol + Phenylephedrine HCl + Caffeine
Used For
Fever & Cough
How it works
Paracetamol works to stop the pain messages from getting through to the brain. It also acts in the brain to reduce fever . Pseudoephedrine is a sympathomimetic with a mixed mechanism of action, direct and indirect. It indirectly stimulates alpha-adrenergic receptors, causing the release of endogenous norepinephrine from the granularity of neurons, while it directly stimulates beta-adrenergic receptors . Codeine binds to mu-opioid receptors, which are involved in the transmission of pain throughout the body and central nervous system . The analgesic properties of codeine are thought to arise from its conversion to Morphine, although the exact mechanism of analgesic action is unknown at this time .
Panadol Cf Usage And Safety
Dosage
Paracetamol + Phenylephedrine HCl + Caffeine
Side Effects
Paracetamol : Thrombocytopaenia, Anaphylaxis cutaneous hypersensitivity reactions including amoung others skin rashes, angiodema, stevens johnson syndrome, toxic epidermal necrosis, bronchospasm in patients sensitive to aspirin and other NSAIDs, hepatic dysfuction. Phenylephrine : Nervousness, Headache, Dizziness, Insomnia, Increased blood pressure, Vomiting, nausea, Mydriasis, acute angle closure glaucoma, most likely to occur in those with closed angle glaucoma Tachycardia, Palpitations Allergic reactions (e.g. rash, urticaria, allergic dermatitis) Dysuria, urinary retention. This is most likely to occur in those with bladder outlet obstruction such as prostatic hypertrophy.
Drug Interactions
Beta blockers and other antihypertensives drugs, monoamine oxidase inhibitors ( avoid ), tricyclic antidepressants, digoxin, cardiac glycosides , other sympathomimetics .
Indication
Panadol Cold + Flu Day tablets can be used for: Nasal and sinus congestion , Colds and Flus
When not to Use
This product is contraindicated in patients: With a previous history of hypersensitivity to paracetamol, pseudoephedrine or excipients.- With severe hypertension or severe coronary artery disease.-Who are receiving other sympathomimetics (such as decongestants, appetite suppressants and amphetamine-like psychostimulants).-Who are receiving Monoamine Oxidase Inhibitors (MAOIs), or for two weeks after stopping a MAOI drug.-With severe renal impairment.
Panadol Cf Precautions
Precaution
Contains paracetamol. Do not use with any other paracetamol-containing products, decongestants, antihistamines or cold and flu medicines. The concomitant use with other products containing paracetamol may lead to an overdose. Paracetamol overdose may cause liver failure which can lead to liver transplant or death.
Panadol Cf Warnings
Warning 1
Caution should be exercised in patients with mild to moderate kidney impairment and in those with hepatic impairment. Underlying liver disease increases the risk of paracetamol-related liver damage.
Warning 2
Cases of hepatic dysfunction/failure have been reported in patients with depleted glutathione levels, such as those who are severely malnourished, anorexic, have a low body mass index or are chronic heavy users of alcohol.
Warning 3
Caution should be exercised in patients with cardiovascular disease, arrhythmias, hypertension, hyperthyroidism, prostatic enlargement, diabetes, glaucoma, phaeochromocytoma, epilepsy, bronchitis, bronchiectasis and bronchial asthma.
Panadol Cf Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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