Description
Description
Metformin 500mg and Vildagliptin 50mg in combination work synergistically to control blood sugar levels. Metformin primarily acts by reducing glucose production in the liver and enhancing insulin sensitivity in peripheral tissues. It inhibits the process of gluconeogenesis and decreases intestinal absorption of glucose. Vildagliptin, on the other hand, is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases insulin secretion from the pancreas in response to meals, and also decreases the production of glucagon, thereby reducing glucose output from the liver. This dual mechanism of action helps to lower blood glucose levels effectively in patients with type 2 diabetes.
Ingredients
Metformin, Vildagliptin
Drug Class
Antidiabetic combination.
Dosage Form
Tablet
Uses
The following are the uses of Metformin 500mg, Vildagliptin 50mg Tablet:
Used for managing type 2 diabetes by controlling blood sugar levels.
Used to improve insulin sensitivity and reduce insulin resistance.
Used to lower glucose production in the liver.
Used to enhance the body’s natural insulin response after meals (post-prandial insulin secretion) with Vildagliptin.
Used to help with weight loss and improve cardiovascular health.
Used to reduce the risk of diabetes-related complications.
Used to promote overall glycemic control and long-term diabetes management.
Dosage
To be determined by the doctor
In case of Overdose
In the case of an overdose of Metformin 500mg and Vildagliptin 50mg Tablet, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and diarrhea. The severity of these symptoms can vary based on the amount ingested. It is important to contact a healthcare professional or seek medical advice promptly if an overdose is suspected. They can provide guidance on the necessary steps to take, which may include inducing vomiting or administering activated charcoal to minimize the absorption of the medication.
Missed Dose
In the case of a missed dose of Metformin 500mg, it is generally recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it’s close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Vildagliptin 50mg, if you miss a dose, take it as soon as you remember, but if it’s near the time for your subsequent dose, skip the missed dose and maintain your regular dosing interval. Do not double the dose to make up for a missed one for either medication.
How To Use
To take the Metformin 500mg and Vildagliptin 50mg Tablet, swallow one tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, ensuring you follow the prescribed dosage and schedule provided.
When Not to Use
Here are the conditions or situations when Metformin 500mg and Vildagliptin 50mg Tablet should not be taken:
Avoid if you have a known allergy to Metformin, Vildagliptin, or any other similar medications.
Not suitable for patients with severe kidney problems or kidney failure.
Should not be used in individuals with diabetic ketoacidosis.
Contraindicated in patients with a history of serious infections, especially in the lungs or urinary tract.
Not recommended for individuals with a history of pancreatitis.
Avoid if you have a severe infection, dehydration, or are going to have surgery.
Should not be used if you have a history of liver disease or liver problems.
Not suitable for individuals with a history of heart disease or recent heart attack.
Contraindicated during pregnancy and breastfeeding.
Do not take if you have a history of alcohol abuse or are currently drinking excessive alcohol.
Side Effects
The side effects of Metformin 500mg, Vildagliptin 50mg Tablet may include:
Nausea and vomiting
Diarrhea
Stomach pain or discomfort
Metallic taste in the mouth
Loss of appetite
Headache
Dizziness or lightheadedness
Skin rash or itching
Precautions & Warnings
Following are the precautions and warnings for Metformin 500mg, Vildagliptin 50mg Tablet:
Patients with a known allergy to Metformin or Vildagliptin should not take this medication.
Regular monitoring of kidney function is necessary, especially in elderly patients and those with kidney issues, as dosage adjustments may be required.
Liver function tests are recommended before starting treatment and periodically during therapy, particularly in patients with pre-existing liver conditions.
Patients with a history of diabetic ketoacidosis should exercise caution, as Metformin can increase the risk of its occurrence.
Alcohol consumption should be avoided or limited while taking this medication, as it may increase the risk of lactic acidosis.
Discontinue use and seek medical attention if symptoms of lactic acidosis appear, such as unusual muscle pain, trouble breathing, stomach discomfort, and feeling cold.
Patients should be aware of the risk of hypoglycemia, especially when combined with other antidiabetic medications or insulin.
Inform your healthcare provider about all the medications you are taking to prevent potential drug interactions.
Drug Interactions
Following are the drug interactions for Metformin 500mg, Vildagliptin 50mg Tablet:
Concurrent use with insulin or insulin secretagogues (e.g., sulfonylureas) may increase the risk of hypoglycemia, requiring careful dose adjustment and monitoring of blood glucose levels.
The effect of metformin on lowering blood glucose may be weakened by certain medications like corticosteroids, beta-agonists, and certain diuretics.
Metformin can interact with contrast agents used in medical imaging procedures, increasing the risk of lactic acidosis. Temporary discontinuation before procedures is recommended.
Vildagliptin may have reduced efficacy when used with rifampicin, a strong CYP3A4 inducer, which can decrease its blood levels.
Alcohol consumption may increase the risk of lactic acidosis, especially in individuals with impaired liver function, and should be avoided or limited.
Drugs that affect kidney function, such as ACE inhibitors or diuretics, may increase metformin levels, requiring dose adjustments and monitoring.
Certain medications metabolized by CYP3A4 may increase the levels of vildagliptin, potentially leading to increased side effects.
Food Interactions
Following are the food interactions for Metformin 500mg, Vildagliptin 50mg Tablet:
Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis, a rare but serious side effect of metformin.
Grapefruit juice should be used cautiously as it may increase the blood levels of vildagliptin, potentially leading to increased side effects.
Consuming a healthy and balanced diet is recommended when taking this medication, as it helps manage blood sugar levels effectively.
Avoid high-fat meals as they can affect the absorption of vildagliptin, potentially reducing its effectiveness.
Maintain a consistent carbohydrate intake to prevent blood sugar fluctuations.
Avoid or limit sugary foods and beverages to prevent rapid spikes in blood glucose levels.
Drink plenty of water to prevent dehydration, especially if experiencing gastrointestinal side effects like diarrhea.
Consider a fiber-rich diet to manage any potential digestive issues, but introduce it gradually to avoid gas and bloating.
Storage/Disposal
Metformin 500mg, Vildagliptin 50mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity. Avoid exposure to extreme temperatures, such as in the bathroom or near heat sources, as this can impact the tablet’s effectiveness. It is crucial to adhere to the medication’s expiration date and dispose of any unused or expired tablets responsibly. Do not dispose of them in sinks, toilets, or drains; instead, consult a pharmacist or healthcare professional for appropriate disposal methods. Always keep medications securely stored, out of the reach of children, to prevent accidental consumption.
Control Drug
No
Quick Tips, if any
Following are the quick tips for Metformin 500mg and Vildagliptin 50mg Tablet:
Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
Swallow the tablets whole with a full glass of water; do not crush, chew, or break them.
Maintain a consistent medication schedule by taking it at the same time each day.
Continue taking the medication even if you feel well, unless advised otherwise by your doctor.
Inform your doctor about all other medications you are taking to avoid potential interactions.
Store the medication in a cool, dry place, away from direct sunlight and moisture.
Do not share your medication with others, even if they have similar symptoms.
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